AUTHOR=Cui Simeng , Zhang Yu , Qiang Qiqi , Liu Ziyu , Liu Peijie , Dang Liangjun , Wang Jin , Lu Wenhui , Huo Kang , Jiang Yu , Chen Chen , Gao Ling , Wei Shan , Feng Junlong , Cao Suixia , Shang Suhang , Qu Qiumin , Zhang Meng 
  
TITLE=Sex- and age-dependent associations between waist-to-hip ratio and cognitive impairment: a cross-sectional study of rural adults aged 40 years and older in northwestern China
  
JOURNAL=Frontiers in Aging Neuroscience
  
VOLUME=Volume 18 - 2026
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1835459
  
DOI=10.3389/fnagi.2026.1835459
  
ISSN=1663-4365
  
ABSTRACT=BackgroundObesity is a modifiable risk factor for cognitive impairment; however, body mass index fails to capture fat distribution. Waist-to-hip ratio (WHR), reflecting central adiposity, may better characterize obesity-related differences in cognitive impairment. Nevertheless, whether the association between WHR and cognitive impairment varies by sex and age remains unclear.MethodsThis cross-sectional study included 1,792 adults aged ≥40 years from rural China. Cognitive impairment was defined using education-adjusted cutoffs on the Chinese Mini-Mental Status. WHR and clinical characteristics were collected by trained investigators. Multivariable logistic regression, restricted cubic splines, stratified analyses, and interaction analyses were performed.ResultsIn the total population, WHR was positively associated with the odds of cognitive impairment (OR = 1.245 per SD, 95% CI: 1.022–1.517, P = 0.029), with borderline evidence of nonlinearity (Poverall = 0.019, Pnonlinear = 0.090). In sex-stratified analyses, the association in females showed evidence of nonlinearity, with the estimated odds remaining relatively stable below a WHR of 0.88 and increasing at higher levels (Poverall = 0.014, Pnonlinear = 0.049), whereas no significant association was observed in males. Age-stratified analyses demonstrated a significant association in the middle-aged group (40–59 years, Poverall = 0.016, Pnonlinear = 0.143) but not in those ≥60 years. Further interaction analyses showed that age appeared to modify the association between WHR and cognitive impairment in males (OR = 0.462 per SD, 95% CI: 0.258–0.828, Pinteraction = 0.010), but not in females. Specifically, the positive association between WHR and cognitive impairment was observed only in middle-aged males (OR = 1.652 per SD, 95% CI: 1.052–2.595, P = 0.029), but not in older males (OR = 0.804 per SD, 95% CI: 0.492–1.314, P = 0.384).ConclusionOur findings show that WHR is associated with screening-defined cognitive impairment, with patterns that may differ by sex and age. Females exhibited a possible nonlinear association, whereas in males the association was mainly observed in midlife. These findings highlight central adiposity as an important correlate of cognitive impairment. Given the rural single-region sample, larger longitudinal studies with clinically adjudicated outcomes are warranted to assess generalizability and clarify temporal associations.