Front. Aging Neurosci. Frontiers in Aging Neuroscience Front. Aging Neurosci. 1663-4365 Frontiers Media S.A. 10.3389/fnagi.2017.00067 Neuroscience Correction Corrigendum: Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice Koivisto Hennariikka 1 Leinonen Henri 1 Puurula Mari 1 Hafez Hani S. 2 Alquicer Barrera Glenda 3 Stridh Malin H. 4 Waagepetersen Helle S. 4 Tiainen Mika 5 Soininen Pasi 5 Zilberter Yuri 6 Tanila Heikki 1 * 1A. I. Virtanen Institute, University of Eastern Finland Kuopio, Finland 2Biology Department, Faculty of Science, Suez University Suez, Egypt 3Institute of Physiology, Czech Academy of Sciences, v.v.i. Prague, Czechia 4Faculty of Health and Medical Sciences, University of Copenhagen Copenhagen, Denmark 5NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland Kuopio, Finland 6Institute de Neurosciences des Systèmes, Aix Marseille Université, Institut National de la Santé et de la Recherche Médicale UMR_S 1106 Marseille, France

Edited and reviewed by: Elizabeth J. Johnson, Tufts University, USA

*Correspondence: Heikki Tanila Heikki.Tanila@uef.fi

 20 03 2017 2017 9 67 01 02 2017 06 03 2017 Copyright © 2017 Koivisto, Leinonen, Puurula, Hafez, Alquicer Barrera, Stridh, Waagepetersen, Tiainen, Soininen, Zilberter and Tanila. 2017 Koivisto, Leinonen, Puurula, Hafez, Alquicer Barrera, Stridh, Waagepetersen, Tiainen, Soininen, Zilberter and Tanila

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 A corrigendum on Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice by Koivisto, H., Leinonen, H., Puurula, M., Hafez, H. S., Alquicer Barrera, G., Stridh, M. H., et al. (2016). Front. Aging Neurosci. 8:41. doi: 10.3389/fnagi.2016.00041 Alzheimer's disease aging memory explorative activity glycogen

In the Original Research article there was an error in the Section “Treatment” under the section “Methods” about the estimated daily intake of pyruvate:

“With the average food intake of 4 g this corresponds to 800 mg of pyruvate/day, which is at the upper range of effective pyruvate doses in earlier in vivo studies (Suh et al., 2005; Fukushima et al., 2009; Isopi et al., 2014).”

As correctly stated in the Abstract, the estimated dose was 800 mg of pyruvate/kg/day.

The corrected version of this section is shown below:

Treatment Chronic pyruvate administration

The test group (PYR) received experimental chow supplemented with 0.6 % (w) of Na-pyruvate (Safe Diets, Augy, France). The control group (STD) received the same basic rodent chow (A04, Safe Diets). With the average food intake of 4 g this corresponds to 800 mg of pyruvate/kg/day, which is at the upper range of effective pyruvate doses in earlier in vivo studies (Suh et al., 2005; Fukushima et al., 2009; Isopi et al., 2014). Acute pyruvate administration. The mice received Na-pyruvate (Sigma, St. Louis, MO, USA) 500 mg/kg i.p. or the same molar concentration of NaCl (260 mg/kg i.p.). This single dose affords neuroprotection against cortical concussion injury and increases brain glucose and pyruvate levels as measured by in vivo microdialysis (Fukushima et al., 2009). All cage labels about the treatment groups were coded so that the researchers running behavioral tests or assays on post-mortem samples were blinded as to the treatment.

 Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.